Heart-specific autoantibodies following murine coxsackievirus B3 myocarditis
نویسندگان
چکیده
The sera from A.SW/SnJ mice infected with Coxsackievirus B3 (CB3) were tested on normal mouse tissue by indirect immunofluorescence. Heart-reactive antibodies were found. Absorption studies with organ extracts showed some of these autoantibodies to be heart-specific. Additional antibodies were crossreactive with skeletal muscle and kidney. These findings suggest a role for autoimmunity in the pathogenesis of murine CB3-induced myocarditis. This study establishes an animal model for the study of the humoral autoimmune response in human viral myocarditis.
منابع مشابه
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ورودعنوان ژورنال:
- The Journal of Experimental Medicine
دوره 161 شماره
صفحات -
تاریخ انتشار 1985